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In the United States, trifarotene is indicated for the topical treatment of acne vulgaris in people nine years of age and older. [6] In both Canada and Australia, it is indicated for the topical treatment of acne vulgaris of the face and/or the trunk in people twelve years of age and older.
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The medication is applied to the skin. [1] Besides its use in medicine, tapinarof is a naturally occurring compound found in bacterial symbionts of nematodes which has antibiotic properties. [2] [3] The medication acts as an aryl hydrocarbon receptor agonist. [1] [4] Tapinarof was approved for medical use in the United States in May 2022.
According to CAS, his visionary view of CAS' potential "led to expansion, modernization, and the forging of international alliances with other information organizations." [15] CAS was an early leader in the use of computer technology to organize and disseminate information. [16] The CAS Chemical Registry System was introduced in 1965.
[1] [2] As a liquid, it is easier to handle than the commonly used N,N ′-dicyclohexylcarbodiimide, a waxy solid. In addition, N,N ′-diisopropylurea, its byproduct in many chemical reactions, is soluble in most organic solvents, a property that facilitates work-up.
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Cream. A cream is a preparation usually for application to the skin.Creams for application to mucous membranes such as those of the rectum or vagina are also used. Creams may be considered pharmaceutical products, since even cosmetic creams are manufactured using techniques developed by pharmacy and unmedicated creams are highly used in a variety of skin conditions (dermatoses).
It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. It is a dye and it stains the skin and may irritate. The hydrochloride form is more irritating than the neutral form. It is derived from acridine. Commercial preparations are often mixtures with proflavine. [1] It is known by a variety of commercial names.