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Dextran is a complex branched glucan ... Dextrans are available in multiple molecular weights ranging from 3 kDa to 2 MDa. The larger dextrans (>60,000 Da) are ...
Dextran sulphate sodium (DSS), or dextran sodium sulphate (or any of the former with "sulfate") is a synthetic sulphated polysaccharide with anticoagulant activity used in immunological research to induce colitis. [1] [2] Dextran polymer molecules with a molecular weight of 36–50 kDa are frequently used to this end. [2]
Changes in the molecular weight of dextran have been shown to alter biological activity, indicating a need for separation and purification processes to ensure batch homogeneity. Dextran, although considered relatively safe and nontoxic in vivo, exhibits a few side effects with the most notable being thrombocytopenia and liver toxicity.
Biotinylated dextran amines (BDA) are organic compounds used as anterograde and retrograde neuroanatomical tracers. ... High molecular weight BDA (10 kDa) yields ...
Acetalated dextran's degradation time can vary from hours to a month or more at pH 7.2. [4] [5] [6] Also, acetalated dextran is unique because it is acid sensitive. Therefore, at lower pH acetalated dextran degrades more rapidly, which results in a polymer that degrades approximately two logs faster at pH 5 compared to pH 7.
Sephadex is a cross-linked dextran gel used for gel filtration. It was launched by Pharmacia in 1959, after development work by Jerker Porath and Per Flodin. [1] [2] The name is derived from separation Pharmacia dextran. It is normally manufactured in a bead form and most commonly used for gel filtration columns. By varying the degree of cross ...
Further development of iron dextran was able to lower these reactions, but also caused more severe gastrointestinal problems. These compounds caused issues mostly because of their high molecular weights. Low molecular weight alternatives were eventually introduced to counter these risks.
The discovery of dye-ligand ability is from a blue dye called blue dextran. ... It has a formula of C 29 H 20 ClN 7 O 11 S 3 and a molecular weight of 774.2 g/mol. [5