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Two distinct drug classes in which cardiotoxicity can occur are in anti-cancer and antiarrhythmic drugs. Anti-cancer drug classes that cause cardiotoxicity include anthracyclines, monoclonal antibodies, and antimetabolites. This form generally manifests as a progressive form of heart failure, but can also manifest as an harmful arrhythmia. [2]
The most common cause of sudden death in the US is coronary artery disease specifically because of poor oxygenation of the heart muscle, that is myocardial ischemia or a heart attack [15] Approximately 180,000 to 250,000 people die suddenly of this cause every year in the US. SADS may occur from other causes.
Arrhythmias occur more commonly in drug-induced LQTS if the medication in question has been rapidly given intravenously, or if high concentrations of the drug are present in the person's blood. [19] The risk of arrhythmias is also higher if the person receiving the drug has heart failure , is taking digitalis , or has recently been cardioverted ...
Early afterdepolarizations can result in torsades de pointes, tachycardia, and other arrhythmias. [3] EADs can be triggered by hypokalemia and drugs that prolong the QT interval, including class Ia and III antiarrhythmic agents, as well as catecholamines. [1] Afterhyperpolarizations can also occur in cortical pyramidal neurons.
Cardiac arrhythmias are another possible cause. Arrhythmias such as asystole or bradycardia are more likely in children, in contrast to ventricular fibrillation or tachycardia as seen in adults. [30] Additional causes of sudden unexplained cardiac arrest in children include hypertrophic cardiomyopathy and coronary artery abnormalities. [161]
Dilated cardiomyopathy is one of the main causes of heart failure. It occurs in about 1 in 2,500 people. Treatment for dilated cardiomyopathy may involve taking medications or surgery to reduce ...
Unnecessary drug therapy. This could occur when the patient has been placed on too many medications for their condition and the drug is simply not needed. [7] Wrong drug. This could occur when a patient is given medication that does not treat the patient's condition. Ex. A heart medication to treat an infection. [7] Dose too low.
Fowler, who was once Maryland’s chief medical examiner, contended that Floyd died from sudden cardiac arrhythmia caused by heart disease during his “restraint and subdual by the police.”
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