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Many countries in the world choose intramuscular injections in newborn to keep them safe from vitamin K deficiency bleeding. It is considered a safe treatment and saves many children from death and severe neurologic deficit every year. [9] Side effects when given by injection may include pain at the site of injection. [7]
Babies receive a shot of vitamin K after birth to prevent life-threatening bleeding. But more parents are refusing the injection. The trend is alarming doctors.
The liver utilizes vitamin K to produce coagulation factors that help the body form blood clots which prevent excessive bleeding. [2] [3] Vitamin K injections are administered to newborns as a preventative measure to reduce the risk of hemorrhagic disease of the newborn (HDN). [4] [5]
Vitamin K deficiency bleeding occurs more frequently in the Asian population compared to the Caucasian population. [19] Bleeding in infants due to vitamin K deficiency can be severe, leading to hospitalization, brain damage, and death. Intramuscular injection, typically given shortly after birth, is more effective in preventing vitamin K ...
Newborn infants have low stores of vitamin K, and human breast milk has low concentrations of the vitamin. This combination can lead to vitamin K deficiency and later onset bleeding. Vitamin K deficiency leads to the risk of blood coagulation problems due to impaired production of clotting factors II, VII, IX, X, protein C and protein S by the ...
Newborn infants are a special case. Plasma vitamin K is low at birth, even if the mother is supplemented during pregnancy, because the vitamin is not transported across the placenta. Vitamin K deficiency bleeding (VKDB) due to physiologically low vitamin K plasma concentrations is a serious risk for premature and term newborn and young infants.
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4-Amino-2-methyl-1-naphthol HCl salt is a vitamin K and prevents bleeding caused by vitamin K deficiency when given via intravenous or intramuscular injections at doses of about 1–3 mg. HCl salt is water-soluble and its parenteral administration requires no emulsifiers [6] [7] unlike fat-soluble phylloquinone for example, which is often in formulations with lecithin or glycocholic acid. [8]