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[1] [2] EE is an estrogen, while norethisterone acetate (NETA) is a progestin. [1] It is taken by mouth. [1] Some preparations of EE/NETA used in birth control additionally contain an iron supplement in the form of ferrous fumarate. [3]
All contain an estrogen, ethinylestradiol or mestranol, [1] [2] in varying amounts, and one of a number of different progestogens. (Regarding the estrogen, the inactive 3-methyl ether of ethinylestradiol, which must be metabolized by the liver into the active ethinylestradiol; 50 μg of mestranol is equivalent to only 35 μg of ethinylestradiol and should not be used when high-dose [50 μg ...
Norethisterone and ethinylestradiol levels over 24 hours after a single oral dose of 10 mg NETA in postmenopausal women. [25] NETA metabolizes into ethinylestradiol at a rate of 0.20 to 0.33% across a dose range of 10 to 40 mg. [26] [27] Peak levels of ethinylestradiol with a 10, 20, or 40 mg dose of NETA were 58, 178, and 231 pg/mL, respectively.
Norethisterone is a substrate for and is known to be an inhibitor of 5α-reductase, with 4.4% and 20.1% inhibition at 0.1 and 1 μM, respectively. [11] However, therapeutic concentrations of norethisterone are in the low nanomolar range, so this action may not be clinically relevant at typical dosages.
A French court found all 51 defendants guilty on Thursday in a mass rape case including Dominique Pelicot, who repeatedly drugged his then wife, Gisele, and allowed dozens of strangers into the ...
However, a recent study of men ages 20 to 44 suggested the following ranges were more accurate based on different age groups: 20-24 years old: 409-558 ng/dL 25-29 years old: 413-575 ng/dL
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