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Telmisartan, sold under the brand name Micardis among others, is a medication used to treat high blood pressure and heart failure. [ 3 ] [ 6 ] It is a reasonable initial treatment for high blood pressure. [ 6 ]
Valsartan, telmisartan and EXP 3174 have similar affinities that are about ten-fold less than that of candesartan. Losartan has the least affinity. [6] ARBs' affinity for the AT 2 receptor is generally much lower (or around 10,000 times less) than for the AT 1 subtype. Therefore, they allow unhindered stimulation of the AT 2 receptor. [20]
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Telmisartan works by blocking the effects of angiotensin II while hydrochlorothiazide works by decreasing the kidneys' ability to retain water. [2] The combination was approved for medical use in the United States in November 2000, [6] [7] and in the European Union in April 2002.
Telmisartan works by blocking the effects of angiotensin II while amlodipine works by decreasing calcium ion entry into smooth muscle and heart muscle. [2] The combination was approved for medical use in the United States in 2009. [2] The combination is on the World Health Organization's List of Essential Medicines.
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