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Once made, the product is released into the plasma, where it is bound to an α-globulin carrier protein named the vitamin D-binding protein. [ 194 ] Calcifediol is transported to the proximal tubules of the kidneys, where it is hydroxylated at the 1-α position (lower right of the molecule) to form calcitriol (1,25-dihydroxycholecalciferol, 1 ...
Nature Made is an American vitamin brand, founded in 1971 by Barry Pressman and Henry Burdick. [1] [2] Operating as a brand of Pharmavite, [3] Nature Made manufactures over 150 different types of supplements. [2] Its parent company, Pharmavite, was acquired by Otsuka Pharmaceutical in 1989. [4] [5] [6]
Pharmavite is an American vitamin and supplement company, based in West Hills, California and founded in 1971 by Barry Pressman and Henry Burdick. Its Nature Made vitamin brand was launched that same year. [2]
Low levels of vitamin D3 are more commonly found in individuals living in northern latitudes or with other reasons for a lack of regular sun exposure, including being housebound, frail, elderly, or obese, having darker skin, and wearing clothes that cover most of the skin. [23] [24] Supplements are recommended for these groups of people. [24]
Ergocalciferol, also known as vitamin D 2 and nonspecifically calciferol, is a type of vitamin D found in food. It is used as a dietary supplement [3] to prevent and treat vitamin D deficiency [4] due to poor absorption by the intestines or liver disease. [5]
Calcifediol supplements have been used in some studies to improve vitamin D status. [4] Indications for their use include vitamin D deficiency or insufficiency, refractory rickets ( vitamin D resistant rickets ), familial hypophosphatemia , hypoparathyroidism , hypocalcemia and renal osteodystrophy and, with calcium, in primary or ...
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