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The packaging for valsartan includes a warning stating the drug should not be used with the renin inhibitor aliskiren in people with diabetes. It also states the safety of the drug in severe renal impairment has not been established. [7] Valsartan includes a black box warning for fetal toxicity.
This list of wars by death toll includes all deaths that are either directly or indirectly caused by war.These numbers include the deaths of military personnel which are the direct results of a battle or other military wartime actions, as well as wartime/war-related deaths of civilians which are often results of war-induced epidemics, famines, genocide, etc. Due to incomplete records, the ...
Developmental toxicity is any developmental malformation that is caused by the toxicity of a chemical or pathogen. It is the structural or functional alteration, reversible or irreversible, which interferes with homeostasis , normal growth , differentiation , development or behavior.
After four years of fighting, the battle represents one of the longest sieges in modern warfare and one of the bloodiest battles of the Syrian Civil War, leaving over 31,000 people dead, [76] [114] almost a tenth of the estimated overall war casualties at that time. [115] Fighting also caused severe destruction to the Old City of Aleppo, a ...
Unit 731 (Japanese: 731部隊, Hepburn: Nana-san-ichi Butai), [note 1] short for Manchu Detachment 731 and also known as the Kamo Detachment [3]: 198 and the Ishii Unit, [5] was a covert biological and chemical warfare research and development unit of the Imperial Japanese Army that engaged in lethal human experimentation and biological weapons manufacturing during the Second Sino-Japanese War ...
The use of valsartan in pregnancy is avoided due to the potential risk of fetal toxicity. [11] The U.S. Food and Drug Administration has a black box warning for valsartan/hydrochlorothiazide use during pregnancy. [2] The use of hydrochlorothiazide is avoided in those with anuria or severe kidney disease. [12]
Fatality totals may be inaccurate or unavailable due to a lack of information. A figure with a plus symbol, indicates that at least that many people have died (e.g. 455+ indicates that at least 455 people have died). Location refers to the states where the main violence takes place, not to the warring parties.
Lexico defined war as "A state of armed conflict between different countries or different groups within a country". [2] Conflicts causing at least 1,000 deaths in one calendar year are considered wars by the Uppsala Conflict Data Program . [ 3 ]