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  2. Duplex sequencing - Wikipedia

    en.wikipedia.org/wiki/Duplex_sequencing

    These types of false-positive variants are filtered out by the duplex sequencing method since mutations need to be accurately matched in both strands of DNA to be validated as true mutations. Duplex sequencing can theoretically detect mutations with frequencies as low as 10 −8 compared to the 10 −2 rate of standard NGS methods. [1] [2] [10]

  3. Molecular Structure of Nucleic Acids: A Structure for ...

    en.wikipedia.org/wiki/Molecular_Structure_of...

    For example, they drew on published research relating to the discovery of Hydrogen bonds in DNA by John Masson Gulland, Denis Jordan and their colleagues at University College Nottingham in 1947. [ 8 ] [ 9 ] [ 10 ] However the discovery of the DNA double helix also used a considerable amount of material from the unpublished work of Rosalind ...

  4. Nucleic acid double helix - Wikipedia

    en.wikipedia.org/wiki/Nucleic_acid_double_helix

    The double-helix model of DNA structure was first published in the journal Nature by James Watson and Francis Crick in 1953, [6] (X,Y,Z coordinates in 1954 [7]) based on the work of Rosalind Franklin and her student Raymond Gosling, who took the crucial X-ray diffraction image of DNA labeled as "Photo 51", [8] [9] and Maurice Wilkins, Alexander Stokes, and Herbert Wilson, [10] and base-pairing ...

  5. Complementarity (molecular biology) - Wikipedia

    en.wikipedia.org/wiki/Complementarity_(molecular...

    Nucleic acids strands may also form hybrids in which single stranded DNA may readily anneal with complementary DNA or RNA. This principle is the basis of commonly performed laboratory techniques such as the polymerase chain reaction, PCR. [1] Two strands of complementary sequence are referred to as sense and anti-sense. The sense strand is ...

  6. DNA sequencing - Wikipedia

    en.wikipedia.org/wiki/DNA_sequencing

    1 to 9 days depending on instrument, read length and number of flow cells run at a time. $5– $120 Sequencing by ligation (SOLiD sequencing) 50+35 or 50+50 bp: 99.9%: 1.2 to 1.4 billion: 1 to 2 weeks: $60–130: Low cost per base. Slower than other methods. Has issues sequencing palindromic sequences. [98] Nanopore Sequencing

  7. Nucleotide excision repair - Wikipedia

    en.wikipedia.org/wiki/Nucleotide_excision_repair

    [1] Nucleotide excision repair is a DNA repair mechanism. [2] DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR).

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  9. Immortal DNA strand hypothesis - Wikipedia

    en.wikipedia.org/wiki/Immortal_DNA_strand_hypothesis

    The immortal DNA strand hypothesis was proposed in 1975 by John Cairns as a mechanism for adult stem cells to minimize mutations in their genomes. [1] This hypothesis proposes that instead of segregating their DNA during mitosis in a random manner, adult stem cells divide their DNA asymmetrically, and retain a distinct template set of DNA strands (parental strands) in each division.