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Airway basal cells are found deep in the respiratory epithelium, attached to, and lining the basement membrane. [1]Basal cells are the stem cells or progenitors of the airway epithelium and can differentiate to replenish all of the epithelial cells including the ciliated cells, and secretory goblet cells.
The cells in the respiratory epithelium are of five main types: a) ciliated cells, b) goblet cells, c) brush cells, d) airway basal cells, and e) small granule cells (NDES) [6] Goblet cells become increasingly fewer further down the respiratory tree until they are absent in the terminal bronchioles; club cells take over their role to some extent here. [7]
A basal cell is a general cell type that is present in many forms of epithelial tissue throughout the body. Basal cells are located between the basement membrane and the remainder of the epithelium, effectively functioning as an anchor for the epithelial layer and an important mechanism in the maintenance of intraorgan homeostasis.
The sustentacular cells function as metabolic and physical support for the olfactory epithelium. Microvillar cells are another class of supporting cells that are morphologically and biochemically distinct from the sustentacular cells, and arise from a basal cell population that expresses the c-KIT cell surface protein. [6]
The basement membrane, also known as base membrane, is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling. [ 1 ] [ 2 ] The basement membrane sits between epithelial tissues including mesothelium and endothelium , and the underlying connective tissue.
Pseudostratified epithelium of the trachea ALI cell culture aims to recreate in vitro. Air liquid interface cell culture (ALI) is a method of cell culture by which basal stem cells are grown with their basal surfaces in contact with media, and the top of the cellular layer is exposed to the air.
The lower respiratory tract is part of the respiratory system, ... Basal cells become further deranged in a smoker's transition to clinically defined COPD. [93]
Brunner's gland cell crypt basal stem cells in duodenum, duodenal submucosa [citation needed] enzyme and alkaline mucus secretion Exocrine secretory epithelial cells Endoderm: Insulated goblet cell: respiratory and digestive tracts mucus secretion Foveolar cell: stomach Chief cell: pepsinogen secretion Parietal cell: hydrochloric acid secretion ...
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