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Peptide therapeutics are peptides or polypeptides (oligomers or short polymers of amino acids) which are used to for the treatment of diseases. Naturally occurring peptides may serve as hormones , growth factors , neurotransmitters , ion channel ligands , and anti-infectives ; peptide therapeutics mimic such functions.
These peptides are potent, broad spectrum antimicrobials which demonstrate potential as novel therapeutic agents. Antimicrobial peptides have been demonstrated to kill Gram negative and Gram positive bacteria, [ 1 ] enveloped viruses, fungi and even transformed or cancerous cells. [ 2 ]
Tirzepatide was approved for treatment of diabetes in the U.S. in May 2022, [9] [13] in the European Union in September 2022, [11] in Canada in November 2022, [19] and in Australia in December 2022. [2] The U.S. Food and Drug Administration (FDA) considers it a first-in-class medication. [20] [21] The FDA approved it for weight loss in November ...
Talquetamab was approved for medical use in both the United States [9] [13] [14] and the European Union [15] in August 2023. The US Food and Drug Administration (FDA) considers it to be a first-in-class medication .
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
Plant cell culture was used to produce FDA-approved glycosylated lysosomal protein-drug, and additional drug candidates. [11] Recent studies have shown that it may be possible to produce recombinant lysosomal proteins with microorganisms such as Escherichia coli and Saccharomyces cerevisiae . [ 12 ]
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