Search results
Results from the WOW.Com Content Network
Recent evidence indicates that the members of the LDL receptor gene family are active in the cell signalling pathways between specialized cells in many, if not all, multicellular organisms. [5] [6] There are seven members of the LDLR family in mammals, namely: LDLR; VLDL receptor ; ApoER2, or LRP8; Low density lipoprotein receptor-related protein 4
This protein belongs to the LDLR family and is made up of a number of functionally distinct domains, including 3 EGF-like domains, 7 LDL-R class A domains, and 6 LDL-R class B repeats. [ 14 ] The N-terminal domain of the LDL receptor, which is responsible for ligand binding, is composed of seven sequence repeats (~50% identical).
Homozygotes have LDLR activity of less than 2%, while heterozygotes have defective LDL processing with receptor activity being 2–25%, depending on the nature of the mutation. Over 1000 different mutations are known. [4] There are five major classes of FH due to LDLR mutations: [12] Class I: LDLR is not synthesized at all.
The LRP1 gene encodes a 600 kDa precursor protein that is processed by furin in the trans-Golgi complex, resulting in a 515 kDa alpha-chain and an 85 kDa beta-chain associated noncovalently. [ 8 ] [ 10 ] [ 11 ] As a member of the LDLR family, LRP1 contains cysteine-rich complement-type repeats, EGF (gene) repeats, β-propeller domains, a ...
The role that is most commonly associated with this evolutionarily ancient gene family is the endocytosis and removal of low-density lipoprotein(LDL), the main carrier of cholesterol in the circulation of humans, by the liver. Indeed, the regulation of cholesterol homeostasis through this mechanism remains the sole known function of the family ...
"[My family has] been around this league almost 30 years, player and coach, and you've seen a lot of things," Pederson said. "If this is the last one, then I can look back and go, 'Hey, it was a ...
Suppression of receptor-binding domain of LRP LDLR is due to overexpression of LRPAP (the protein product of LRPAP gene). [13] LRP gives protection across LDL by LRPAP and its downregulation may be subjected for an elevation of LDL and Ab-related neuronal toxicity as LRP supports in binding of ligand and internalization of LRP ligands like apo ...
Here are nine great benefits of a 529 plan and why this plan could be right for you and your family: 1. Tax-free growth for education. A 529 plan gives you a tax-advantaged way to save for ...