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The LDLR gene resides on chromosome 19 at the band 19p13.2 and is split into 18 exons. [8] Exon 1 contains a signal sequence that localises the receptor to the endoplasmic reticulum for transport to the cell surface.
The members of the LDLR family are characterized by distinct functional domains present in characteristic numbers. These modules are: LDL receptor type A (LA) repeats of 40 residues each, displaying a triple-disulfide-bond-stabilized negatively charged surface; certain head-to-tail combinations of these repeats are believed to specify ligand ...
4043 16976 Ensembl ENSG00000163956 ENSMUSG00000029103 UniProt P30533 P55302 RefSeq (mRNA) NM_002337 NM_013587 RefSeq (protein) NP_002328 NP_038615 Location (UCSC) Chr 4: 3.5 – 3.53 Mb Chr 5: 35.25 – 35.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Alpha-2-MRAP_N haddock model of the complex between double module of lrp, cr56, and first domain of receptor associated protein ...
The LRP1 gene encodes a 600 kDa precursor protein that is processed by furin in the trans-Golgi complex, resulting in a 515 kDa alpha-chain and an 85 kDa beta-chain associated noncovalently. [ 8 ] [ 10 ] [ 11 ] As a member of the LDLR family, LRP1 contains cysteine-rich complement-type repeats, EGF (gene) repeats, β-propeller domains, a ...
A bispecific monoclonal antibody (BsMAb, BsAb) is an artificial protein that can simultaneously bind to two different types of antigen or two different epitopes on the same antigen. [1] Naturally occurring antibodies typically only target one antigen. BsAbs can be manufactured in several structural formats.
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
238055 Ensembl ENSG00000084674 ENSMUSG00000020609 UniProt P04114 E9Q414 RefSeq (mRNA) NM_000384 NM_009693 RefSeq (protein) NP_000375 NP_033823 Location (UCSC) Chr 2: 21 – 21.04 Mb Chr 12: 8.03 – 8.07 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. Its measurement is commonly used to detect risk of ...
The "upper" part of an antibody. The complementarity-determining regions of the heavy chain are shown in red (Complementarity-determining regions (CDRs) are polypeptide segments of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively. CDRs are where these molecules bind to their ...
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