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BioSteel was a trademark name for a high-strength fiber-based material made of the recombinant spider silk-like protein extracted from the milk of transgenic goats, made by defunct Montreal-based company Nexia Biotechnologies, and later by the Randy Lewis lab of the University of Wyoming and Utah State University. [1]
The silk is a complex form of protein fiber that starts off as a protein-rich liquid and then dries into solid filaments, thanks to spinnerets, an external portion of spider glands.
Kim Kraig Thompson, a retired lawyer, invented the protein expression platform in 2002, which would become the basis for Kraig Lab's work with spider silk. [3] He founded Kraig Biocraft Laboratories in April 2006 to develop and commercialize spider silks and other high-performance polymers gene and sequences using platform technology in combination with genetic engineering concepts.
Spider silk fibril is composed of stiff crystallized β-sheets structure, responsible for strength, and amorphous matrix surrounding, improving toughness and elongation ability. [16] It has exceptionally high tensile strength and ductility, with respectively low density, compared to other natural fibril.
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Silk proteins present in other spider silk types are also occasionally referred to as spidroin. These include tubuliform silk protein (TuSP), flagelliform silk protein (Flag; O44358 - Q9NHW4 - O44359 ), minor ampullate silk proteins (MiSp; K4MTL7 ), aciniform silk protein (AcSP), pyriform silk protein (PySp) and aggregate silk glue (ASG2/AgSp).
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