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Cotrimoxazole: This is an antibiotic which incorporates sulphonamides and trimethoprim. It covers a broad spectrum of activity and in dentistry, is often used where there are clear signs and indications of bacterial infection that is sensitive to cotrimoxazole. This is determined by bacteriological sensitivity tests. [11]
Clinical trials have confirmed its efficacy, with or without adjunctive doxycycline; although, co-trimoxazole alone seems preferable. [38] [39] [40] Pertussis (whooping cough) No: No: No: One cochrane review supports its efficacy in preventing the spread of pertussis. [41] Shigellosis: Yes: Yes: No: Generally accepted treatment for shigellosis ...
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Co-trimoxazole is recommended for what used to be called Wegener granulomatosis limited to the upper respiratory tract, because of its favorable adverse effect profile compared to the other treatments.