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The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response. [19]
As a result of the high false positive rate in the US, as many as 90–95% of women who get a positive mammogram do not have the condition. The lowest rate in the world is in the Netherlands, 1%. The lowest rates are generally in Northern Europe where mammography films are read twice and a high threshold for additional testing is set (the high ...
The false positive rate (FPR) is the proportion of all negatives that still yield positive test outcomes, i.e., the conditional probability of a positive test result given an event that was not present. The false positive rate is equal to the significance level. The specificity of the test is equal to 1 minus the false positive rate.
After five years of additional experimental work, Rutherford and Hans Geiger determined that "the alpha particle, after it has lost its positive charge, is a Helium atom". [7] [8] [9]: 61 Alpha radiation consists of particles equivalent to doubly-ionized helium nuclei (He 2+) which can gain electrons from passing through matter. This mechanism ...
Alpha is a measure of the active return on an investment, the performance of that investment compared with a suitable market index.An alpha of 1% means the investment's return on investment over a selected period of time was 1% better than the market during that same period; a negative alpha means the investment underperformed the market.
Lindsay added, “So they have the ‘alpha’ which is the most successful, the best looking and then they have ‘sigma’ which is the same thing as an alpha but humbler.” Another definition ...
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Depending on type of the thermistor in question the may be either positive or negative. If is positive, the ... ("alpha sub T") is used. It is defined as [6]