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Positive inotropes are used to support cardiac function in conditions such as decompensated congestive heart failure, cardiogenic shock, septic shock, myocardial infarction, cardiomyopathy, etc. [10] Examples of positive inotropic agents include: [ citation needed ]
Cardiotonic agents, also known as cardiac inotropes or stimulants, have a positive impact on the myocardium (muscular layer of the heart) by enhancing its contractility. . Unlike general inotropes, these agents exhibit a higher level of specificity as they selectively target the myocar
A "heterocycle-phenyl-imidazole" (H-P-I) pattern has been considered to be necessary for positive inotropic activity in cardiac muscle and many second generation inhibitors fit this pattern. [ 6 ] The heterocycle region : Within each heterocycle there is the presence of a dipole and an adjacent acid proton (an amide function).
Haemorrhagic shock: Hypovolemia (Hypovolemic shock) Intravascular volume status Heart rate (Tachycardia) / Systolic blood pressure (Hypotension) / Decreased urine output: Intravenous fluid / Intraosseous infusion / Blood transfusion with packed red blood cells: Cardiogenic shock: Cardiac output: Positive inotropic agents / Chronotropes ...
Dobutamine is used to treat acute but potentially reversible heart failure, such as which occurs during cardiac surgery or in cases of septic or cardiogenic shock, on the basis of its positive inotropic action. [6] Dobutamine can be used in cases of congestive heart failure to increase cardiac output.
Septic shock, especially septic shock where treatment is delayed or the antimicrobial drugs are ineffective, however has a mortality rate between 30% and 80%; cardiogenic shock has a mortality rate of up to 70% to 90%, though quick treatment with vasopressors and inotropic drugs, cardiac surgery, and the use of assistive devices can lower the ...
Both inotropic and lusitropic effects justify the use of amrinone to treat heart failure. Amrinone decreases the pulmonary capillary wedge pressure while increasing cardiac output, as it functions as an arterial vasodilator and increases venous capacitance while decreasing venous return. [ 5 ]
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