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Symptoms: Decreased level of consciousness, poor coordination, vomiting, abdominal pain, specific smell on the breath [1] [2] Complications: Blindness, kidney failure [1] Causes: Methanol (such as found in windshield washer fluid) [1] [2] Diagnostic method: Blood acidosis, increased osmol gap, methanol blood level [1] [2] Differential diagnosis
The CDKN2A gene is located on chromosome 9p21.3. Two main transcripts, isoforms '1' and '4', each contain three exons and span 7288 and 26740 bp, respectively. They encode proteins of 156 and 173 amino acids; isoform '1' encodes p16(INK4a), while isoform '4' encodes p14(ARF), a protein that is structurally unrelated to p16(INK4) but acts in cell cycle G1 control by stabilizing the tumor ...
Acral lentiginous melanoma (ALM) is a type of skin cancer. [6] It typically begins as a uniform brownish mark before becoming darker and wider with a blurred, irregular border. ALM is most frequently seen on the foot of a person with darker skin but can also be found in non-sun exposed areas such as the palms , soles , and under finger and ...
The word melanoma has a long history of being used in a broader sense to refer to any melanocytic tumor, typically, but not always malignant, [170] [171] but today the narrower sense referring only to malignant types has become so dominant that benign tumors are usually not called melanomas anymore and the word melanoma is now usually taken to ...
Melanoma symptoms and signs Melanoma tumors tend to be black or brown, but can sometimes be pink, tan or white. Anyone can get melanoma, but people with light skin are at greater risk.
In comparison, the mortality rate of melanoma is 15–20% and it causes 6500 deaths per year. [67]: 29, 31 Even though it is much less common, malignant melanoma is responsible for 75% of all skin cancer-related deaths. [68] The survival rate for people with melanoma depends upon when they start treatment.
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Superficial spreading melanoma (SSM) is a type of skin cancer that typically starts as an irregularly edged dark spot typically on sun-exposed part of the body. [ 2 ] [ 3 ] The colour may be variable with dark, light and reddish shades; occasionally no color at all. [ 2 ]