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Alpha-gal syndrome (AGS), also known as alpha-gal allergy or mammalian meat allergy (MMA), [1] is a type of acquired allergy characterized by a delayed onset of symptoms (3–8 hours) after ingesting mammalian meat. The condition results from past exposure to certain tick bites and was first reported in 2002.
What is alpha-gal syndrome? The lone star tick can cause an allergic reaction known as alpha-gal syndrome. The tick's saliva contains a sugar molecule called galactose-alpha-1,3-galactose (alpha-gal).
Here’s everything you need to know about alpha-gal syndrome. Here’s everything you need to know about alpha-gal syndrome. Skip to main content. Subscriptions; Animals. Business. Entertainment ...
In a person with alpha-gal syndrome, symptoms typically appear two to six hours after eating or being exposed to the molecule, and can include: Hives or itchy rash Nausea or vomiting
When the same tick attaches to the next host (e.g., a human) it transfers the alpha-gal to the tissues of that next host. The immune system of some humans recognises alpha-gal as foreign and so produces antibodies against it. In this case the antibody produced is IgE, which is the type of antibody responsible for most allergic reactions.
Galactose-α-1,3-galactose, commonly known as alpha gal and the Galili antigen, is a carbohydrate found in most mammalian cell membranes. It is not found in catarrhines , [ 1 ] including humans, who have lost the GGTA1 gene.
The range of symptoms is vast; alpha-gal syndrome can cause hives, heartburn, nausea or vomiting, diarrhea, drops in blood pressure, dizziness, severe stomach pain, and even anaphylaxis.
Alpha-gal sounds like a sorority nickname, but it is short for the sugar galactose-alpha-1,3-galactose.
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