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Over expression of this gene is associated with the grade of the malignancy and proliferative activity in gliomas and melanomas. [7] An increased expression of MSI1 protein is observed in endometriosis and endometrial carcinoma [8] siRNA-mediated inhibition of MSI expression in endometrial carcinoma cells induces apoptosis and inhibits cell proliferation by affecting the Notch signaling ...
Low testosterone or testosterone deficiency, also known as hypogonadism, is a condition in which patients develop symptoms.
Muscarinic acetylcholine receptors belong to a class of metabotropic receptors that use G proteins as their signaling mechanism. In such receptors, the signaling molecule (the ligand) binds to a monomeric receptor that has seven transmembrane regions; in this case, the ligand is ACh. This receptor is bound to intracellular proteins, known as G ...
The first musashi (abbreviation MSI) gene was first discovered in Drosophila and then later identified in other eukaryotic species. MSI2 is involved in organismal development. [ 12 ] As with the rest of Musashi family RNA-binding proteins, MSI2 is linked to tissue stem cells and has an influence in asymmetric cell division, germ and somatic ...
Both M 2 and M 3 muscarinic receptors are expressed in the smooth muscles of the airway, with the majority of the receptors being the M 2 type. Activation of the M 2 receptors, which are coupled to G i, inhibits the β-adrenergic mediated relaxation of the airway smooth muscle.
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse.The cell receiving the signal, or target cell, may be another neuron, but could also be a gland or muscle cell.
Animation showing the function of a chemical synapse. There are two different kinds of synapses present within the human brain: chemical and electrical. Chemical synapses are by far the most prevalent and are the main player involved in excitatory synapses.
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events. Proteins responsible for detecting stimuli are generally termed receptors , although in some cases the term sensor is used. [ 1 ]