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Calyx of Held microstructure. The calyx of Held is a particularly large excitatory synapse in the mammalian auditory nervous system, so named after Hans Held who first described it in his 1893 article Die centrale Gehörleitung [1] [2] because of its resemblance to the calyx of a flower. [3]
The ossicles (also called auditory ossicles) are three irregular bones in the middle ear of humans and other mammals, and are among the smallest bones in the human body. . Although the term "ossicle" literally means "tiny bone" (from Latin ossiculum) and may refer to any small bone throughout the body, it typically refers specifically to the malleus, incus and stapes ("hammer, anvil, and ...
The middle ear is the portion of the ear medial to the eardrum, and distal to the oval window of the cochlea (of the inner ear). The mammalian middle ear contains three ossicles (malleus, incus, and stapes), which transfer the vibrations of the eardrum into waves in the fluid and membranes of the inner ear .
In humans, the ear is described as having three parts: the outer ear, the middle ear and the inner ear. The outer ear consists of the auricle and the ear canal . Since the outer ear is the only visible portion of the ear, the word "ear" often refers to the external part (auricle) alone. [ 1 ]
The synaptic cleft—also called synaptic gap—is a gap between the pre- and postsynaptic cells that is about 20 nm (0.02 μ) wide. [12] The small volume of the cleft allows neurotransmitter concentration to be raised and lowered rapidly.
The cartoon depicts a GABAergic synapse in adult rat brain where GABA is released exocytotically and acts upon specific post-synaptic receptors. The signal is terminated by removal of GABA from the synaptic cleft by transport of GABA back into the nerve terminal by the plasma membrane GABA transporter (GAT) 1.
232333 Ensembl ENSG00000157103 ENSMUSG00000030310 UniProt P30531 P31648 RefSeq (mRNA) NM_003042 NM_001348250 NM_001348251 NM_001348252 NM_001348253 NM_178703 RefSeq (protein) NP_003033 NP_001335179 NP_001335180 NP_001335181 NP_001335182 NP_848818 Location (UCSC) Chr 3: 10.99 – 11.04 Mb Chr 6: 114.26 – 114.29 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse GABA transporter 1 (GAT1 ...
Normally, transporters in the synaptic membrane serve to remove neurotransmitters from the synaptic cleft and prevent their action or bring it to an end. However, on occasion transporters can work in reverse, transporting neurotransmitters into the synapse, allowing these neurotransmitters to bind to their receptors and exert their effect.