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Ibuprofen/paracetamol, sold under the brand name Combogesic among others, is a fixed-dose combination of two medications, ibuprofen, a non-steroidal anti-inflammatory drug (NSAID); and paracetamol (acetaminophen), an analgesic and antipyretic. [6] It is available as a generic medication. [9] [10] [11]
Calpol also comes in a form containing ibuprofen, marketed under the name Calprofen. Calpol Night, a product containing paracetamol and an antihistamine, was listed for use from 2+ months. However, this was changed and it is now only considered suitable for children over the age of 6 years. [4]
The correlation between the severity of symptoms and measured ibuprofen plasma levels is weak. Toxic effects are unlikely at doses below 100 mg/kg, but can be severe above 400 mg/kg (around 150 tablets of 200 mg units for an average adult male); [47] however, large doses do not indicate the clinical course is likely to be lethal. [48]
Paracetamol's bioavailability is dose-dependent: it increases from 63 % for 500 mg dose to 89 % for 1000 mg dose. [6] Its plasma terminal elimination half-life is 1.9–2.5 hours, [6] and volume of distribution is roughly 50 L. [132] Protein binding is negligible, except under the conditions of overdose, when it may reach 15–21 %. [6]
The Dane County Medical Examiner's Office on Wednesday identified the victims of the school shooting as Rubi Patricia Vergara, 14, and Erin West, 42.
Pyrilamine maleate 15 mg (antihistamine) The "Extended Relief" formulation consists of: Naproxen sodium 220 mg (NSAID, pain reliever/fever reducer) The "Teen" formulation consists of: Acetaminophen 500 mg (pain reliever) Pamabrom 25 mg ; The "Liquid Gels" (Labeled MAXIDOL) [8] formulation consists of: Ibuprofen 200 mg (NSAID, pain reliever)
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