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Biguanide (/ b aɪ ˈ ɡ w ɒ n aɪ d /) is the organic compound with the formula HN(C(NH)NH 2) 2. It is a colorless solid that dissolves in water to give a highly basic solution. It is a colorless solid that dissolves in water to give a highly basic solution.
The lactic acidosis occurred only in patients with a buformin plasma level of greater than 0.60 μg/mL and was rare in patients with normal renal function. [ 19 ] [ 20 ] [ 21 ] In one report, the toxic oral dose was 329 ± 30 mg/day in 24 patients who developed lactic acidosis on buformin.
Toxic units (TU) are used in the field of toxicology to quantify the interactions of toxicants in binary mixtures of chemicals. [1] A toxic unit for a given compound is based on the concentration at which there is a 50% effect (ex. EC50) for a certain biological endpoint. One toxic unit is equal to the EC50 for a given endpoint for a specific ...
The researchers analyzed historical data on childhood blood-lead levels, leaded gas use and U.S. population statistics, determining that more than 170 million Americans had "clinically concerning ...
Ozempic, Wegovy and other GLP-1 drugs have been shown to curb alcoholism, a new study suggests. Researchers explain why diabetes and weight loss drugs work better than alcohol medications.
Earlier studies found mean elimination rates of 15 mg/dL per hour for men and 18 mg/dL per hour for women, [6] [4] but Jones found 0.148 g/L/h and 0.156 g/L/h respectively. Although the difference between sexes is statistically significant, it is small compared to the overall uncertainty, so Jones recommends using the value 0.15 for the mean ...
The average life expectancy for women is 80.2 years, per the CDC, which means women spend about a third of their life in this post-menopausal phase. So, while women live longer, on average, than ...
Long and co-workers also [10] conducted a meta-analysis using 1068 sediment toxicity assays to evaluate the predictive ability of the ERL/ERM, PEL (predicted effects level), and TEL (threshold effects level) sediment quality guidelines. They found that the ERL most accurately predicted no-effects toxicity in benthic organisms. Furthermore, it ...