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Triton X-100 (C 14 H 22 O(C 2 H 4 O) n) is a nonionic surfactant that has a hydrophilic polyethylene oxide chain (on average it has 9.5 ethylene oxide units) and an aromatic hydrocarbon lipophilic or hydrophobic group.
Surfactant therapy is the medical administration of pulmonary surfactant that is derived from outside of the body. Pulmonary surfactant is a soap-like chemical synthesized by type II alveolar pneumocytes and is of various lipids (80% phospholipids, 5-10% cholesterol, and ∼10% surfactant-associated proteins).
Biodegradable and plant-derived from sugars, these surfactants are usually derivatives of glucose and fatty alcohols. [1] The raw materials are typically starch and fat , and the final products are typically complex mixtures of compounds with different sugars comprising the hydrophilic end and alkyl groups of variable length comprising the ...
Poractant alfa is an extract of natural porcine lung surfactant. As with other surfactants, marked improvement on oxygenation may occur within minutes of the administration of poractant alfa. The new generic form of surfactant is Varasurf (Sheep Lung Surfactant) developed in PersisGen Co. and commercialized by ArnaGen Pharmad.
Nonylphenol is also often used an intermediate in the manufacture of the non-ionic surfactants nonylphenol ethoxylates, which are used in detergents, paints, pesticides, personal care products, and plastics.
Calfactant, also known as Infasurf, [1] is an intratracheal suspension derived from the natural surfactant in calf lungs. It is used in premature infants with lung surfactant deficiency that causes infant respiratory distress syndrome (IRDS).
Studies have shown that WLL can be used to deplete surfactant, followed by the administration of surfactant replacement therapies. This approach helps improve lung function and oxygenation in conditions like neonatal ARDS.WLL is not a standard treatment for ARDS but is used in research settings to model and study ARDS treatment strategies.