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Contemporary commercial products for the topical treatment of flea infestations on pets contain pesticides such as imidacloprid, permethrin, and (S)-methoprene. All flea-control products are recommended to be used at least half-yearly because the lifecycle of flea can last up to a year. [ 5 ]
Methoprene is a juvenile hormone (JH) analog which acts as a growth regulator when used as an insecticide (IRAC group 7A). It is an amber-colored liquid with a faint fruity odor. Methoprene does not kill insects. Instead, it interferes with an insect’s life cycle and prevents it from reaching maturity or reproducing. [2]
The 2017 fipronil eggs contamination is an incident in Europe and South Korea involving the spread of insecticide contaminated eggs and egg products. Chicken eggs were found to contain fipronil and distributed to 15 European Union countries, Switzerland , and Hong Kong .
In 2005, the U.S. EPA cancelled permission to use phenothrin in several flea and tick products, at the request of the manufacturer, Hartz Mountain Industries. [7] [8] The products were linked to a range of adverse reactions, including hair loss, salivation, tremors, and numerous deaths in cats and kittens. In the short term, the agreement ...
After the structure determination of the JHs in the 1960s, the search for more stable and useable analogs started. Zoecon introduced methoprene in 1975, and later hydroprene and kinoprene. Later again other companies introduced the more stable fenoxycarb and pyriproxyfen. They are in IRAC group 7.
The US Food and Drug Administration (FDA) approved it for flea treatment in dogs in May 2014, [17] and approved the combination fluralaner/moxidectin (Bravecto Plus) as a topical treatment for cats in November 2019.
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