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A 2007 Cochrane review assessed the side effects of short-term use of pseudoephedrine at recommended doses as a nasal decongestant. [21] It found that pseudoephedrine had a small risk of insomnia and this was the only side effect that occurred at rates significantly different from placebo. [21]
A wide variety of alkaloid and non-alkaloid compounds have been identified in various species of ephedra.Of the six ephedrine-type ingredients found in ephedra (at concentrations of 0.02-3.4%), the most common are ephedrine and pseudoephedrine, [12] which are the sources of its stimulant and thermogenic effects. [3]
Pseudoephedrine acts indirectly on the adrenergic receptor system, whereas phenylephrine and oxymetazoline are direct agonists. The effects are not limited to the nose, and these medicines may cause hypertension (high blood pressure) through vasoconstriction ; it is for this reason that people with hypertension are advised to avoid them.
Ephedrine is a non-catecholamine sympathomimetic with cardiovascular effects similar to those of adrenaline/epinephrine: increased blood pressure, heart rate, and contractility. Like pseudoephedrine it is a bronchodilator, with pseudoephedrine having considerably less effect. [19] [20]
It contains fexofenadine, as the hydrochloride, an antihistamine; and pseudoephedrine, as the hydrochloride, a nasal decongestant. [ 2 ] In 2021, it was the 279th most commonly prescribed medication in the United States, with more than 800,000 prescriptions.
A Clarinase Repetab tablet contains 5 mg loratadine in the tablet coating and 120 mg pseudoephedrine sulfate equally distributed between the tablet coating and the barrier-coated core. The two active components in the coating are quickly liberated; release of pseudoephedrine in the core is delayed for several hours.
Cetirizine/pseudoephedrine (Zyrtec-D) is an antihistamine and decongestant formulation. It is a fixed-dose combination drug containing 5 mg cetirizine hydrochloride and 120 mg pseudoephedrine hydrochloride for symptoms related to seasonal allergic rhinitis .
Naproxen/pseudoephedrine, sold under the brand name Aleve-D among others, is a fixed-dose combination medication used for the treatment of nasal congestion and other symptoms of the common cold. [1] It contains naproxen , as the sodium salt, a nonsteroidal anti-inflammatory drug (NSAID); and pseudoephedrine , as the hydrochloride, a nasal ...
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