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Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.. It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, such as carbon tetrachloride, or far more pervasively in the form of ethanol (drinking alcohol).
Download as PDF; Printable version; ... Drugs and other substances that have been associated with significant hepatotoxicity (liver damage). ...
Hepatotoxicity. [3] Clometacin: 1987 France Hepatotoxicity. [3] Co-proxamol (Distalgesic) 2004 UK Risk of overdose Cyclobarbital: 1980 Norway Risk of overdose [3] Cyclofenil: 1987 France Hepatotoxicity. [3] Dantron: 1963 Canada, UK, US Mutagenic. [15] withdrawn from general use in UK but permitted in terminal patients Dexfenfluramine: 1997 ...
Of these, amoxicillin-clavulanate is the most common cause of drug-induced liver injury, and paracetamol toxicity the most common cause of acute liver failure in the United States and Europe. [36] Herbal remedies and dietary supplements are another important cause of hepatitis; these are the most common causes of drug-induced hepatitis in Korea ...
between 280,000 and 400,000, ranking obesity as the second leading preventable cause of death, just behind tobacco use (David B. Allison et al.1999 and Ali H. Mokdad et al. 2004). Economic analyses of this trend have implicated a variety of potential causes,
Drug-drug interactions can be of serious concern for patients who are undergoing multi-drug therapies. [5] Coadministration of chloroquine , an anti-malaria drug, and statins for treatment of cardiovascular diseases has been shown to cause inhibition of organic anion-transporting polypeptides (OATPs) and lead to systemic statin exposure.
You already know that drinking alcohol can wreak havoc on your liver. (And if you don't, well, here are more details on those dangers.) Now, a new study links a drink popular specifically for its ...