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With abstinence from alcohol and cross-tolerant drugs these changes in neurochemistry may gradually return towards normal. [ 22 ] [ 23 ] Adaptations to the NMDA system also occur as a result of repeated alcohol intoxication and are involved in the hyper-excitability of the central nervous system during the alcohol withdrawal syndrome.
Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme aldehyde dehydrogenase (specifically the ALDH2 enzyme [3]), causing many of the effects of a hangover to be felt immediately following alcohol consumption.
Naltrexone has been shown to decrease the quantity and frequency of ethanol consumption by reducing the dopamine release from the brain after consuming alcohol. [19] [20] [21] It does not appear to change the percentage of people drinking. [22] Its overall benefit has been described as "modest". [23] [19] [24] [25]
“The best way to moderate alcohol consumption is to stop drinking for four weeks, and then after this period of abstinence, ... (like using a medication to block cravings), to name a few ...
How to stop drinking Depending on whether you’re a light or heavy drinker, your strategy around cutting back will be different. “For a light drinker, you don’t really need to taper,” says ...
White also warns that it can be dangerous to quit drinking alcohol on your own if you’ve been drinking heavily for a period of time. “Each year, alcohol withdrawal contributes to about 1,000 ...
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