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  2. Xanomeline/trospium chloride - Wikipedia

    en.wikipedia.org/wiki/Xanomeline/trospium_chloride

    Xanomeline was licensed to Karuna Therapeutics in 2012 and KarXT was subsequently created as a dual drug formulation by adding trospium. Trospium is a non-brain-penetrant and non-selective muscarinic receptor blocker that may ameliorate the peripheral side effects of xanomeline.

  3. Karuna Therapeutics' Schizophrenia Drug Could Be a ... - AOL

    www.aol.com/karuna-therapeutics-schizophrenia...

    If Karuna is successful, its drug would offer relief to a large patient population. According to the World Health Organization, schizophrenia affects approximately 24 million people, or one in 300 ...

  4. Xanomeline - Wikipedia

    en.wikipedia.org/wiki/Xanomeline

    Xanomeline is an agonist that primarily targets the muscarinic acetylcholine receptor family of five muscarinic receptor subtypes, which are designated M 1-M 5. [2] While it binds with near identical affinity to all five of the muscarinic receptor subtypes as measured by displacement of a muscarinic radioligand, the preponderance of evidence suggests that xanomeline acts preferentially in the ...

  5. List of herbs with known adverse effects - Wikipedia

    en.wikipedia.org/wiki/List_of_herbs_with_known...

    "Potentiates digitalis activity, increases coronary dilation effects of theophylline, caffeine, papaverine, sodium nitrate, adenosine and epinephrine, increase barbiturate-induced sleeping times" [3] Horse chestnut: conker tree, conker Aesculus hippocastanum: Liver toxicity, allergic reaction, anaphylaxis [3] Kava: awa, kava-kava [4] Piper ...

  6. 15 Bizarre Side Effects of Foods You Probably Have in Your ...

    www.aol.com/15-bizarre-side-effects-foods...

    7. Soy Can Affect Fertility in Men. Soy has come a long way. Once dismissed as “hippie food,” today it’s a popular protein alternative for vegetarians and vegans.

  7. Bristol Myers to buy schizophrenia drugmaker Karuna ...

    www.aol.com/news/bristol-myers-buy-schizophrenia...

    Karuna's drug is expected to be patent-protected in the United States through the mid-2030s. The deal is expected to hit Bristol Myers' earnings per share by roughly 30 cents in 2024 due to the ...

  8. Steven M. Paul - Wikipedia

    en.wikipedia.org/wiki/Steven_M._Paul

    [19] [20] As of 2020, he was on the board of directors or is a trustee of several organizations, including serving as chairman of the Board of the Foundation for the NIH (FNIH) [21] and as a Director of Alnylam Pharmaceuticals, [22] Sage Therapeutics, [23] Voyager Therapeutics [24] and Karuna Pharmaceuticals. [25]

  9. Side effect - Wikipedia

    en.wikipedia.org/wiki/Side_effect

    Possible side effects of nicotine [2] [3] The World Health Organization and other health organisations characterise the probability of experiencing side effects as: [4] [5] Very common, ≥ 1 ⁄ 10; Common (frequent), 1 ⁄ 10 to 1 ⁄ 100; Uncommon (infrequent), 1 ⁄ 100 to 1 ⁄ 1000; Rare, 1 ⁄ 1000 to 1 ⁄ 10000; Very rare, < 1 ⁄ 10000

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