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In ICP8, the herpes simplex virus (HSV-1) single-strand DNA-binding protein (ssDNA-binding protein (SSB)), the head consists of the eight alpha helices.The front side of the neck region consists of a five-stranded beta-sheet and two alpha helices, whereas the back side is a three-stranded beta-sheet The shoulder part of the N-terminal domain contains an alpha-helical and beta-sheet region. [1]
Single-strand DNA-binding protein (SSB) is a protein found in Escherichia coli (E. coli) bacteria, that binds to single-stranded regions of deoxyribonucleic acid (). [1] Single-stranded DNA is produced during all aspects of DNA metabolism: replication, recombination, and repair.
, Mt-SSB, SOSS-B1, SSBP, mtSSB, single stranded DNA binding protein 1, OPA13: External IDs Gene location ... Single-stranded DNA-binding protein, ...
Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. [1] [2] In vitro, RPA shows a much higher affinity for ssDNA than RNA or double-stranded DNA. [3] RPA is required in replication, recombination and repair processes such as nucleotide excision repair and homologous recombination.
Single-stranded DNA is highly unstable and can form hydrogen bonds with itself that are referred to as 'hairpins' (or the single strand can improperly bond to the other single strand). To counteract this instability, single-strand binding proteins (SSB in prokaryotes and Replication protein A in eukaryotes) bind to the exposed bases to prevent ...
The RPA process employs three core enzymes – a recombinase, a single-stranded DNA-binding protein (SSB) and strand-displacing polymerase. Recombinases are capable of pairing oligonucleotide primers with homologous sequence in duplex DNA. [1] SSB bind to displaced strands of DNA and prevent the primers from being displaced.
RecG releases bound proteins and the PriA helicase facilitates DNA reloading to resume DNA replication. RecG replaces the single-strand binding protein (SSB), which regulates the helicase-fork loading sites during fork regression. The SSB protein interacts with DNA helicases PriA and RecG to recover stalled DNA replication forks.
Replication restart is a multi-step process in E. coli that requires the sequential action of several proteins. When the progress of the replication fork is impeded the proteins single-stranded binding protein SSB and RecG helicase along with the RuvABC complex are required for rescue. [2]
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