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  2. dnaB helicase - Wikipedia

    en.wikipedia.org/wiki/DnaB_helicase

    DnaB helicase is an enzyme in bacteria which opens the replication fork during DNA replication.Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerisation of the N-terminal domain has been observed and may occur during the enzymatic cycle. [1]

  3. Helicase - Wikipedia

    en.wikipedia.org/wiki/Helicase

    Helicases move incrementally along one nucleic acid strand of the duplex with a directionality and processivity specific to each particular enzyme. Helicases adopt different structures and oligomerization states. Whereas DnaB-like helicases unwind DNA as ring-shaped hexamers, other enzymes have been shown to be active as monomers or dimers.

  4. DnaA - Wikipedia

    en.wikipedia.org/wiki/DnaA

    DnaC helps the helicase to bind to and to properly accommodate the ssDNA at the 13 bp region; this is accomplished by ATP hydrolysis, after which DnaC is released. Single-strand binding proteins (SSBs) stabilize the single DNA strands in order to maintain the replication bubble. DnaB is a 5'→3' helicase, so it travels on the lagging strand.

  5. Primosome - Wikipedia

    en.wikipedia.org/wiki/Primosome

    The primosome consists of seven proteins: DnaG primase, DnaB helicase, DnaC helicase assistant, DnaT, PriA, Pri B, and PriC. At each replication fork, the primosome is utilized once on the leading strand of DNA and repeatedly, initiating each Okazaki fragment, on the lagging DNA strand. Initially the complex formed by PriA, PriB, and PriC binds ...

  6. DNA unwinding element - Wikipedia

    en.wikipedia.org/wiki/DNA_unwinding_element

    The DNA helicase and associated enzymes are now able to bind to the unwound region, creating a replication fork start. The unwinding of this duplex strand region is associated with a low free energy requirement, due to helical instability caused by specific base-stacking interactions, in combination with counteracting supercoiling.

  7. Prokaryotic DNA replication - Wikipedia

    en.wikipedia.org/wiki/Prokaryotic_DNA_replication

    The DnaC helicase loader then interacts with the DnaA bound to the single-stranded DNA to recruit the DnaB helicase, [9] which will continue to unwind the DNA as the DnaG primase lays down an RNA primer and DNA Polymerase III holoenzyme begins elongation. [10]

  8. DnaB - Wikipedia

    en.wikipedia.org/wiki/DnaB

    DnaB may refer to: DNA helicase, an enzyme class; dnaB helicase, a bacterial enzyme This page was last edited on 28 December 2019, at 07:34 (UTC). Text is available ...

  9. Replisome - Wikipedia

    en.wikipedia.org/wiki/Replisome

    This helicase translocates in the same direction as the DNA polymerase (3' to 5' with respect to the template strand). In prokaryotic organisms, the helicases are better identified and include dnaB, which moves 5' to 3' on the strand opposite the DNA polymerase.