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1982 – "T4 gene 41 protein" is the first reported bacteriophage DNA helicase [15] 1985 – First mammalian DNA helicases isolated from calf thymus [17] 1986 – SV40 large tumor antigen reported as a viral helicase (1st reported viral protein that was determined to serve as a DNA helicase) [18]
Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene. WRN is a member of the RecQ Helicase family. [ 5 ] Helicase enzymes generally unwind and separate double-stranded DNA .
DnaB helicase is an enzyme in bacteria which opens the replication fork during DNA replication.Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerisation of the N-terminal domain has been observed and may occur during the enzymatic cycle. [1]
The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. [1] [2] As a critical protein for cell division, MCM is also the target of various checkpoint pathways, such as the S-phase entry and S-phase arrest ...
The gene CHD8 encodes the protein chromodomain helicase DNA binding protein 8, [7] which is a chromatin regulator enzyme that is essential during fetal development. [8] CHD8 is an ATP dependent enzyme. [9] The protein contains an Snf2 helicase domain that is responsible for the hydrolysis of ATP to ADP. [9]
A 3D representation of the RRM3 protein, as modelled by SWISS-MODEL. RRM3 is a gene that encodes a 5′-to-3′ DNA helicase [1] known affect multiple cellular replication and repair processes and is most commonly studied in Saccharomyces cerevisiae.
Bloom syndrome protein is a protein that in humans is encoded by the BLM gene and is not expressed in Bloom syndrome. [5]The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities.
RecQ helicase is a family of helicase enzymes initially found in Escherichia coli [1] that has been shown to be important in genome maintenance. [2] [3] [4] They function through catalyzing the reaction ATP + H 2 O → ADP + P and thus driving the unwinding of paired DNA and translocating in the 3' to 5' direction.
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