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PSGAG is first administered as a series of injections over several weeks, and can be continued once or twice a month thereafter. [10] It is normally injected intramuscularly, though can also be injected intra-articularily (directly into the joint) in horses or subcutaneously in off-label uses. [2]
The treatment of equine lameness is a complex subject. Lameness in horses has a variety of causes, and treatment must be tailored to the type and degree of injury, as well as the financial capabilities of the owner. Treatment may be applied locally, systemically, or intralesionally, and the strategy for treatment may change as healing progresses.
Another study examined both the serum and the joint synovial fluid after nasogastric (oral) or intravenous administration of 20 mg/kg glucosamine hydrochloride to eight adult horses. [48] Although joint fluid concentrations of glucosamine reached 9–15 μmol/L following intravenous dosing, it was only 0.3–0.7 μmol/L with nasogastric dosing.
One group of common alternative treatments are nutraceutical supplements. The most popular of these are joint supplements such as glucosamine, chondroitin, MSM, and hyaluronic acid. Related to joint supplements are various treatments for pain, viewed as alternatives to the common mainstream pain-reducing medications phenylbutazone, and banamine ...
While it is a prescription or over-the-counter drug in 22 countries, chondroitin is regulated in the U.S. as a dietary supplement [36] by the Food and Drug Administration. In Europe, chondroitin sulfate formulations are approved as drugs with evidenced efficacy and safety demonstrated by clinical trials in people with osteoarthritis. [37]
According to the NIH Office of Dietary Supplements, older adults ages 51–70 years are recommended 600 International Units (IU) or 15 mcg of vitamin D daily, while those ages 70 years and older ...
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