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Non-HFE associated hemochromatosis, as Haemochromatosis type 2, Haemochromatosis type 3, Haemochromatosis type 4 and Haemochromatosis type 5, [10] were discovered in Mediterranean countries. On the other side, Northern European ancestry is closely linked to hereditary hemochromatosis disease (HFE).
His father was an architect. His mother, Frances Irene Forrester, was a schoolteacher. Crosby was drawn toward medicine at an early age, attaching himself at age 12 to volunteer physicians who worked at the Boy scout camp he attended. In high school he discovered his love of literature from his sophomore English teacher, Dorothy Mann.
The syndrome has several other names, such as "primary hemochromatosis", "bronze diabetes", "pigmentary cirrhosis" and "iron overload disease". It is named with two other French physicians, Charles Emile Troisier (1844–1919) and Anatole Chauffard (1855–1932).
Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Treatment for hemochromatosis type 3 may include reducing iron levels by removing blood (phlebotomy), iron chelation therapy, diet changes, and treatment for complications of the disease. The purpose of the treatment is to reduce the amount of iron in the body to normal levels, prevent or delay organ damage from excess iron, and maintain normal ...
At least 42 mutations involving HFE introns and exons have been discovered, most of them in persons with hemochromatosis or their family members. [25] Most of these mutations are rare. Many of the mutations cause or probably cause hemochromatosis phenotypes, often in compound heterozygosity with HFE C282Y. Other mutations are either synonymous ...
Tom Warder, Marie's husband, whose fight with hemochromatosis was the catalyst for her crusade against this disorder. In 1975, Warder's husband, Tom, who had been seriously ill for eight years, was finally diagnosed with hemochromatosis at the age of 50, [14] and died in 1992. [15] In 1979 their daughter, then 32, was also diagnosed with ...
Charles Richard Drew (June 3, 1904 – April 1, 1950) was an American surgeon and medical researcher. He researched in the field of blood transfusions, developing improved techniques for blood storage, and applied his expert knowledge to developing large-scale blood banks early in World War II.