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Lactocillin is a thiopeptide antibiotic which is encoded for and produced by biosynthetic genes clusters in the bacteria Lactobacillus gasseri. Lactocillin was discovered and purified in 2014. [1] Lactobacillus gasseri is one of the four Lactobacillus bacteria found to be most common in the human vaginal microbiome. [2]
Lactobacillus is a genus of gram-positive, aerotolerant anaerobes or microaerophilic, rod-shaped, non-spore-forming bacteria. [2] [3] Until 2020, the genus Lactobacillus comprised over 260 phylogenetically, ecologically, and metabolically diverse species; a taxonomic revision of the genus assigned lactobacilli to 25 genera (see § Taxonomy below).
Infection occurs in about 30% of women who are taking a course of antibiotics by mouth. [2] Broad-spectrum antibiotics kill healthy bacteria in the vagina, such as Lactobacillus. These bacteria normally help to limit yeast colonization. [14] [15] Oral contraceptive use is also associated with increased risk of vaginal thrush. [16] [2]
LACTIN-V is a live biopharmaceutical medication containing the vaginally important Lactobacillus crispatus which is under development for the treatment of bacterial vaginosis and recurrent urinary tract infections. [68] [69] [70] It has shown initial effectiveness in considerably reducing recurrence of bacterial vaginosis following antibiotic ...
The amount and type of bacteria present have significant implications for an individual's overall health. [2] The primary colonizing bacteria of a healthy individual are of the genus Lactobacillus, [3] such as L. crispatus, and the lactic acid they produce is thought to protect against infection by pathogenic species. [4]
Treatment can include topical steroids to diminish the inflammation. Antibiotics to diminish the proportion of aerobic bacteria is still a matter of debate. The use of local antibiotics, preferably local non-absorbed and broad spectrum, covering enteric gram-positive and gram-negative aerobes, can be an option.
Lactobacillus crispatus is a normal inhabitant of the lower reproductive tract in healthy women. [17] [18] Functionally, like other lactic acid-producing bacteria, it may prevent infections through production of lactic acid, thereby lowering the pH. [19] Condom use was correlated with increased colonization of Lactobacillus crispatus in the ...
Lactobacillus jensenii is a lactic acid bacteria species in the genus Lactobacillus. It is one of the four main species of Lactobacillus considered to be the major part of the vaginal flora, along with Lactobacillus crispatus, Lactobacillus gasseri, and Lactobacillus iners. [1] [2] L. jensenii is sometimes used in producing fermented foods. [3]