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Rifampicin can reduce the efficacy of birth control pills or other hormonal contraception by its induction of the cytochrome P450 system, to the extent that unintended pregnancies have occurred in women who use oral contraceptives and took rifampicin even for very short courses (for example, as prophylaxis against exposure to bacterial meningitis).
Management of tuberculosis refers to techniques and procedures utilized for treating tuberculosis (TB), or simply a treatment plan for TB.. The medical standard for active TB is a short course treatment involving a combination of isoniazid, rifampicin (also known as Rifampin), pyrazinamide, and ethambutol for the first two months.
Rifapentine in pregnant women has not been studied, but animal reproduction studies have resulted in fetal harm and were teratogenic. If rifapentine or rifampin are used in late pregnancy, coagulation should be monitored due to a possible increased risk of maternal postpartum hemorrhage and infant bleeding.
It is a fixed dose combination of ethambutol, isoniazid, pyrazinamide, and rifampicin. [1] ... It is unclear if use during pregnancy is safe. [3]
Dapsone is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. [3] It is also used to both treat and prevent pneumocystis pneumonia (PCP). [3] [9] It is also used for toxoplasmosis in people unable to tolerate trimethoprim with sulfamethoxazole. [9]
Lepetit introduced Rifampicin, an orally active rifamycin, in 1966. [16] Rifabutin, a derivative of rifamycin S, was invented by Italian drug manufacturer Achifar in 1975 and came onto the US market in 1992. [16] Hoechst Marion Roussel (now part of Aventis) introduced rifapentine to the US market in 1998, with Achifar having synthesized it in ...
For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide. [4] It is administered by injection into a vein or muscle. [3] Common side effects include vertigo, vomiting, numbness of the face, fever, and rash. [3] Use during pregnancy may result in permanent deafness in the developing baby. [3]
Isoniazid, also known as isonicotinic acid hydrazide (INH), is an antibiotic used for the treatment of tuberculosis. [4] For active tuberculosis, it is often used together with rifampicin, pyrazinamide, and either streptomycin or ethambutol. [5]