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Goblet cells are simple columnar epithelial cells that secrete gel-forming mucins, like mucin 2 in the lower gastrointestinal tract, and mucin 5AC in the respiratory tract. [1] The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under ...
The cells in the respiratory epithelium are of five main types: a) ciliated cells, b) goblet cells, c) brush cells, d) airway basal cells, and e) small granule cells (NDES) [6] Goblet cells become increasingly fewer further down the respiratory tree until they are absent in the terminal bronchioles; club cells take over their role to some extent here. [7]
MUC5B is a polymeric protein secreted from submucosal glands and some goblet cells, and this is in the form of strands. [9] [10] In the airways—the trachea, bronchi, and bronchioles—the lining of mucus is produced by specialized airway epithelial cells called goblet cells, and submucosal glands.
The mucous membrane is thickest, and most vascular, over the nasal conchae. It is also thick over the nasal septum where increased numbers of goblet cells produce a greater amount of nasal mucus. It is very thin in the meatuses on the floor of the nasal cavities, and in the various sinuses. It is one of the most commonly infected tissues in ...
The respiratory tract is covered in epithelium, which varies down the tract. There are glands and mucus produced by goblet cells in parts, as well as smooth muscle, elastin or cartilage. The epithelium from the nose to the bronchioles is covered in ciliated pseudostratified columnar epithelium, commonly called respiratory epithelium. [12]
The submucosal glands are a companion to goblet cells which also produce mucus, and are found lining the same tubes. [2] In the upper respiratory system of mammals there are submucosal glands in the airways, notably in the sinuses, the trachea and the bronchial tubes. [1] In the visual systems of mammals. In the auditory systems of mammals.
Mucus is a normal protective layering around the airway, eye, nasal turbinate, and urogenital tract. Mucus is an adhesive viscoelastic gel produced in the airway by submucosal glands and goblet cells and is principally water. It also contains high-molecular weight mucous glycoproteins that form linear polymers.
Mucociliary clearance (MCC), mucociliary transport, or the mucociliary escalator describes the self-clearing mechanism of the airways in the respiratory system. [1] It is one of the two protective processes for the lungs in removing inhaled particles including pathogens before they can reach the delicate tissue of the lungs.