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AMPylator setting up target protein with ATP for AMPylation reaction. Adenylylation, [1] [2] more commonly known as AMPylation, is a process in which an adenosine monophosphate (AMP) molecule is covalently attached to the amino acid side chain of a protein. [3]
The pyrophosphate bond is also sometimes referred to as a phosphoanhydride bond, a naming convention which emphasizes the loss of water that occurs when two phosphates form a new P−O−P bond, and which mirrors the nomenclature for anhydrides of carboxylic acids.
ATP is often called a high energy compound and its phosphoanhydride bonds are referred to as high-energy bonds. There is nothing special about the bonds themselves. They are high-energy bonds in the sense that free energy is released when they are hydrolyzed, for the reasons given above. Lipmann’s term "high-energy bond" and his symbol ~P ...
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Browser version: Published by MobiSystems, Inc.: Includes 350,000 words, 75,000 audio pronunciations in both British and American voices. Version 2.1.0.4 (full version, 2015-04-07): Oxford References online edition
Structure of ATP Structure of ADP Four possible resonance structures for inorganic phosphate. ATP hydrolysis is the catabolic reaction process by which chemical energy that has been stored in the high-energy phosphoanhydride bonds in adenosine triphosphate (ATP) is released after splitting these bonds, for example in muscles, by producing work in the form of mechanical energy.
These compounds are linear polymers containing a few to several hundred residues of orthophosphate linked by energy-rich phosphoanhydride bonds. Previously, it was considered either as “ molecular fossil ” or as only a phosphorus and energy source providing the survival of microorganisms under extreme conditions.
Throughout Wikipedia, the pronunciation of words is indicated using the International Phonetic Alphabet (IPA). The following tables list the IPA symbols used for English words and pronunciations. Please note that several of these symbols are used in ways that are specific to Wikipedia, and differ from those used by dictionaries.