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Levinthal's paradox is a thought experiment in the field of computational protein structure prediction; protein folding seeks a stable energy configuration. An algorithmic search through all possible conformations to identify the minimum energy configuration (the native state) would take an immense duration; however in reality protein folding happens very quickly, even in the case of the most ...
Protein-truncating variants ... umbrella term frameshift or truncating variants (FTVs), which includes both PTVs and DNA variants caused by frameshift mutation. ...
An "RCCX theory", a hypothesis developed by Sharon Meglathery, a US psychiatrist, [40] an author of a few publications on psychiatry, [41] [42] and oncology, [43] [44] highlights the links between certain autoimmune and psychiatric disorders due to variations in the RCCX cluster. According to the hypothesis, these variations contribute to the ...
Evolutionary psychologists consider Charles Darwin's theory of natural selection to be important to an understanding of psychology. [1] Natural selection occurs because individual organisms who are genetically better suited to the current environment leave more descendants, and their genes spread through the population, thus explaining why organisms fit their environments so closely. [1]
The molecular clock is a figurative term for a technique that uses the mutation rate of biomolecules to deduce the time in prehistory when two or more life forms diverged.The biomolecular data used for such calculations are usually nucleotide sequences for DNA, RNA, or amino acid sequences for proteins.
Neutral networks are a subset of the sequences in sequence space that have equivalent function, and so form a wide, flat plateau in a fitness landscape. Neutral evolution can therefore be visualised as a population diffusing from one set of sequence nodes, through the neutral network, to another cluster of sequence nodes.
According to the theory, such a mental model is used to predict input signals from the senses that are then compared with the actual input signals from those senses. Predictive coding is member of a wider set of theories that follow the Bayesian brain hypothesis.
Point mutations can have several effects on the behavior and reproduction of a protein depending on where the mutation occurs in the amino acid sequence of the protein. If the mutation occurs in the region of the gene that is responsible for coding for the protein, the amino acid may be altered.