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Loss of heterozygosity does not imply a homozygous state (which would require the presence of two identical alleles in the cell). The exact targets for LOH are not characterised for all chromosomal losses in cancer, but certain are very well mapped.
In human genome, the cluster let-7a-1/let-7f-1/let-7d is inside the region B at 9q22.3, with the defining marker D9S280-D9S1809.One minimal LOH (loss of heterozygosity) region, between loci D11S1345-D11S1316, contains the cluster miR-125b1/let-7a-2/miR-100.
RecLOH is a term in genetics that is an abbreviation for "Recombinant Loss of Heterozygosity".. This is a type of mutation which occurs with DNA by recombination.From a pair of equivalent ("homologous"), but slightly different (heterozygous) genes, a pair of identical genes results.
Loss of heterozygosity (LOH) is a technique that can only be used to compare two samples from the same individual. LOH analysis is often used when identifying cancer-causing oncogenes in that one sample consists of (mutant) tumor DNA and the other (control) sample consists of genomic DNA from non-cancerous cells from the same individual.
One of the most frequent genetic abnormalities that occur in advanced colorectal cancer is loss of heterozygosity (LOH) of DCC in region 18q21. DCC in a receptor for netrin-1 and is currently believed by some to be a conditional tumour suppressor gene, meaning that it normally prevents cell growth when in the absence of netrin-1.
The status of the 1p/19q loci can be detected by FISH, loss of heterozygosity (LOH) analysis or virtual karyotyping. Virtual karyotyping has the advantage of assessing the entire genome in one assay, as well as the 1p/19q loci. This allows assessment of other key loci in glial tumors, such as EGFR and TP53 copy number status.
[23] [24] The second hit event in LAM cells is often loss of the chromosomal region containing the wild-type copy of the TSC2 gene; this is referred to as loss of heterozygosity or LOH. [25] LOH can be detected in microdissected LAM cells, [ 21 ] [ 26 ] in angiomyolipomas and lymph nodes from women with LAM, [ 27 ] and in circulating LAM cells ...
In humans, the NKX3-1 gene is located on chromosome 8p21.2 with 4 exons. [7] The 8p chromosome is a region that is frequently reported to undergo a loss of heterozygosity (LOH) associated with tissue dedifferentiation and loss of androgen responsiveness during the progression of prostate cancer.