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Low energy levels and stress: The AMP-dependent protein kinase AMPK phosphorylates and thereby activates TSC1-TSC2 by phosphorylating at least 2 residues of TSC2. [7] Hypoxia: The Hypoxia-inducible factor α HIFα induces REDD1 at low oxygen levels. REDD1 has been shown to activate TSC1-TSC2 by neutralisation of AKT dependent inhibition. [8]
The Personal System/2 Model 60 is a high-end desktop computer in IBM's Personal System/2 (PS/2) family of personal computers. First released in April 1987, the Model 60 features an Intel 80286 processor running at a clock speed of 10 MHz, the same as its midrange counterpart, the Personal System/2 Model 50 .
TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. TSC1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including TSC2, therefore preventing their ubiquitination and degradation in the proteasome. [6]
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Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis. [8]The defective degradation of glycogen by the autophagy-lysosome pathway is, at least in part, independent of impaired regulation of mTORC1 and is restored by the combined use of PKB/Akt and mTORC1 pharmacological inhibitors.
A baby died after a hospital did not induce labor for more than 60 hours, a lawsuit alleges. Chelsea Wootton, 31, was scheduled to be induced at 41 weeks pregnant, her law firm Irwin Mitchell said ...
A diet rich in fruits, vegetables, whole grains, fish, legumes, and dairy may help lower the risk of gastrointestinal cancers, including colorectal cancer, recent research suggests.
The PS/2 Model 50 was introduced in April 1987 alongside the lower-end Model 30 and the higher-end Model 60.The PS/2 Model 50, as well as the Model 60, served as the public market introduction of the Micro Channel architecture (MCA), a proprietary bus standard designed by IBM to replace the aging Industry Standard Architecture (ISA) first used in their earlier IBM PCs.