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Eurycomanone is a chemical compound that has been isolated from Eurycoma longifolia, also known as the longjack plant or tongkat ali. [1] Eurycomanone is distributed throughout the plant, with the highest concentration in leaves. Researchers measured 6.0568 μg/mL in leaves, and only 0.3533 μg/mL in roots. [2]
Eurycoma longifolia (commonly called tongkat ali, Malaysian ginseng or long jack) [3] is a flowering plant in the family Simaroubaceae. It is native to Indochina (Cambodia, Laos, Malaysia, Myanmar, Thailand and Vietnam) and Indonesia (the islands of Borneo and Sumatra ), [ 4 ] but has also been found in the Philippines. [ 5 ]
However, the amount Tongkat Ali raises T levels is not to any significant effect. “For most guys, it’s only going to raise your levels 30 points or so, which isn’t enough to meaningfully ...
The similarities, at molecular level, of an estrogen and a phytoestrogen allow them to mildly mimic and sometimes act as an antagonist of estrogen. [2] Phytoestrogens were first observed in 1926, [ 2 ] [ 5 ] but it was unknown if they could have any effect in human or animal metabolism.
One of them is whether these new drugs raise or lower your testosterone levels. About one in eight Americans have taken a glucagon-like peptide-1 (GLP-1) agonist medication, like Ozempic or Wegovy ...
During this transition, the body stops releasing estrogen at a faster rate than it stops releasing androgens. In some cases, the difference between the lower estrogen levels and higher androgen levels can produce hyperandrogenism. A decrease in sex hormone levels while the free androgen index increases can also contribute to this process. [51]
Unlike the GnRH agonists, which cause an initial stimulation of the hypothalamic–pituitary–gonadal axis (HPG axis) that leads to a surge in testosterone or estrogen levels, GnRH antagonists have an immediate onset of action and rapidly reduce sex hormone levels without an initial surge.
Tongkat Ali (a.k.a. Long Jack) is marketed by several off-shore sources, trumpeted as a testosterone booster, without the side-effects of direct testosterone supplementation. In what appear to be limited trials, results reported include 200% to 400% increase in testosterone and free testerone levels. This seems remarkable.
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