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Cytokinesis illustration Ciliate undergoing cytokinesis, with the cleavage furrow being clearly visible. Cytokinesis (/ ˌ s aɪ t oʊ k ɪ ˈ n iː s ɪ s /) is the part of the cell division process and part of mitosis during which the cytoplasm of a single eukaryotic cell divides into two daughter cells.
In animals the cytokinesis ends with formation of a contractile ring and thereafter a cleavage. But in plants it happen differently. At first a cell plate is formed and then a cell wall develops between the two daughter cells. [36] In Fission yeast the cytokinesis happens in G1 phase. [37]
In molecular biology, an actomyosin ring or contractile ring, is a prominent structure during cytokinesis. [1] It forms perpendicular to the axis of the spindle apparatus [ 2 ] towards the end of telophase , in which sister chromatids are identically separated at the opposite sides of the spindle forming nuclei (Figure 1).
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
FtsZ acts as an organizer protein and is required for cell division. It is the first component of the septum during cytokinesis, and it recruits all other known cell division proteins to the division site. [9] Despite this functional similarity to actin, FtsZ is homologous to eukaryal tubulin.
During cytokinesis in animal cells, a contractile ring made up of actin filaments forms, and this ring pinches to divide the cell into two daughter cells. [6] The cells are able to separate due to the formation of a cleavage furrow, which pinches in a centripetal fashion (from the outside of the cell towards the center of the cell). [6]
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During this time, necessary mitotic proteins are produced and the cell is once more subjected to regulatory mechanisms to ensure proper status for entry into the proliferative Mitotic (M) phase. Multiple mechanistic checkpoints are involved in this transition from G2 to M, with a common uniting factor of cyclin-Cdk activity.