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Aortic stenosis is most commonly caused by age-related progressive calcific aortic valve disease (CAVD) (>50% of cases), with a mean age of 65 to 70 years. CAVD is the build-up of calcium on the cusps of the valve, and this calcification causes hardening and stenosis of the valve. [ 22 ]
Heyde's syndrome; A stenotic aortic valve: Specialty: Cardiology, general surgery, Hematology: Symptoms: Aortic valve stenosis symptoms: Chest pain (angina) or tightness Shortness of breath, especially during exertion or when lying down Fatigue or weakness Irregular heartbeat or heart palpitations Dizziness or fainting episodes Gastrointestinal bleeding symptoms: Occult (hidden) or overt ...
An aortic aneurysm often doesn’t cause symptoms, but it can lead to severe, sudden bleeding from a ruptured aneurysm. A ruptured aneurysm has a high risk of death. If symptoms of an aortic ...
Aortic stenosis due to calcification of tricuspid aortic valve with age [16] comprises >50% of the disease. Aortic stenosis due to calcification of a bicuspid aortic valve [16] comprises about 30-40% [15] of the disease. Hypertension, diabetes mellitus, hyperlipoproteinemia and uremia may speed up the process of valvular calcification. [15]
Another important cause of aortic stenosis is chronic rheumatic fever, which can cause repeated inflammation and repair, leading to fibrosis. In this case, the leaflets can actually fuse together, called commissural fusion, which can be an important distinction from the type caused by mechanical stress over time.
Calcification outside of the vascular smooth muscle cells are commonly associated with damage to elastic fibers in the extra-cellular matrix. These calcium deposits also develop on the internal elastic lamina. Stage 2 and Stage 3 involve the formation of calcified sheaths spanning an increased diameter through the tunica media.
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