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Ketamine makes people feel like their mind and body are separate, Dr. Boyer explains. “People who use it who aren’t using an anesthetic dose will clump around because they can’t feel their ...
Ketamine potentiates the sedative effects of propofol [85] and midazolam. [86] Naltrexone potentiates psychotomimetic effects of a low dose of ketamine, [87] while lamotrigine [38] and nimodipine [39] decrease them. Clonidine reduces the increase of salivation, heart rate, and blood pressure during ketamine anesthesia and decreases the ...
Unlike traditional antidepressants that target the neurotransmitters serotonin and/or norepinephrine, ketamine targets glutamate — the most abundant chemical messenger in the brain, Feifel said.
Ketamine crystals on a glass plate. K-hole is the feeling of getting a high enough dose of ketamine to experience a state of dissociation.This intense detachment from reality is often a consequence of accidental overconsumption of ketamine; however, some users consciously seek out the k-hole as they find the powerful dissociative effects to be quite pleasurable and enlightening.
A 2000 landmark study showcased the drug's antidepressant and anti-suicidal effects, and more recent studies have supported ketamine's high rate of success in treating persistent depression.
Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]
The high levels of ketamine found in his blood could cause "lethal effects" from cardiovascular overstimulation and respiratory depression, the Los Angeles County medical examiner said in a report.
Ketamine is a hallucinogen that was approved by the Food and Drug Administration as an anesthetic for surgery decades ago, but it’s also used illegally as a party drug.