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A melanocytic nevus (also known as nevocytic nevus, nevus-cell nevus, and commonly as a mole) [1] [2] is usually a noncancerous condition of pigment-producing skin cells. It is a type of melanocytic tumor that contains nevus cells . [ 2 ]
Melanocytic tumors are tumors developed from melanocytes. [1] [2] Types. Melanocytic nevus; Melanocytic tumors of uncertain malignant potential; Melanoma; References
A benign melanocytic nevus is a cutaneous condition characterised by well-circumscribed, pigmented, round or ovoid lesions, generally measuring from 2 to 6 mm in diameter. [1] A benign melanocytic nevus may feature hair or pigmentation as well.
A related category of melanocytic proliferation is superficial atypical melanocytic proliferations of uncertain significance (SAMPUS). This category, unlike MELTUMP, which implies as yet undetermined potential for metastases even after complete excision, signifies lesions without metastatic potential at time of excision but with potential to ...
Melanocytic nevi and neoplasms are caused by either a proliferation of (1) melanocytes, or (2) nevus cells, a form of melanocyte, but which lack dendritic processes.
A melanocytoma is a rare pigmented tumor that has been described as a variant of the melanocytic nevus [1] and is derived from the neural crest. [2] The term "melanocytoma" was introduced by Limas and Tio in 1972.
HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas. It is used in anatomic pathology as a marker for such tumors. The antibody was generated to an extract of melanoma. It reacts positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity.
It is a type of melanocytic tumor occurring in intermittently sun-exposed skin. [2] The cause is associated with repeated sunburns in childhood, intermittent exposure to sun during life, and sun bed use. [2] Two-thirds of cases occur in light skin, and it is less common in dark skin. [2] The average age at diagnosis is in the fifth decade.