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  2. Haemophilia - Wikipedia

    en.wikipedia.org/wiki/Haemophilia

    Haemophilia C is an autosomal genetic disorder involving a lack of functional clotting Factor XI. Haemophilia C is not completely recessive, as heterozygous individuals also show increased bleeding. [42] The type of haemophilia known as parahaemophilia is a mild and rare form and is due to a deficiency in factor V.

  3. Haemophilia in European royalty - Wikipedia

    en.wikipedia.org/wiki/Haemophilia_in_European...

    Tests on the remains of the Romanov imperial family show that the specific form of haemophilia passed down by Queen Victoria was probably the relatively rare haemophilia B. [1] The presence of haemophilia B within the European royal families was well-known, with the condition once popularly known as "the royal disease".

  4. Haemophilia B - Wikipedia

    en.wikipedia.org/wiki/Haemophilia_B

    Haemophilia B, also spelled hemophilia B, is a blood clotting disorder causing easy bruising and bleeding due to an inherited mutation of the gene for factor IX, and resulting in a deficiency of factor IX. It is less common than factor VIII deficiency (haemophilia A). [3] Haemophilia B was first recognized as a distinct disease entity in 1952. [4]

  5. Haemophilia A - Wikipedia

    en.wikipedia.org/wiki/Haemophilia_A

    Diagnosis of haemophilia A also includes a severity level, which can range from mild to severe based on the amount of active and functioning factor VIII detected in the blood. Factor VIII levels do not typically change throughout an individual's lifetime. Severe haemophilia A is the most common severity, occurring in the majority of affected ...

  6. Coagulation - Wikipedia

    en.wikipedia.org/wiki/Coagulation

    The three main forms are hemophilia A (factor VIII deficiency), hemophilia B (factor IX deficiency or "Christmas disease") and hemophilia C (factor XI deficiency, mild bleeding tendency). [ 54 ] Von Willebrand disease (which behaves more like a platelet disorder except in severe cases), is the most common hereditary bleeding disorder and is ...

  7. Factor VIII - Wikipedia

    en.wikipedia.org/wiki/Factor_VIII

    2157 14069 Ensembl ENSG00000185010 ENSMUSG00000031196 UniProt P00451 Q06194 RefSeq (mRNA) NM_000132 NM_019863 NM_001161373 NM_001161374 NM_007977 RefSeq (protein) NP_000123 NP_063916 NP_001154845 NP_001154846 NP_032003 Location (UCSC) Chr X: 154.84 – 155.03 Mb Chr X: 74.22 – 74.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Coagulation factor VIII (Factor VIII, FVIII, also ...

  8. Contaminated haemophilia blood products - Wikipedia

    en.wikipedia.org/wiki/Contaminated_haemophilia...

    Contaminated hemophilia blood products were a serious public health problem in the late 1970s up to 1985. Hemophilia A causes a deficiency in Factor VIII , a protein required for blood clotting. Factor VIII injections are a common treatment to prevent or stop bleeding in people with hemophilia A. [ 1 ]

  9. Timeline of the evolutionary history of life - Wikipedia

    en.wikipedia.org/wiki/Timeline_of_the...

    The earliest evidence for life on Earth includes: 3.8 billion-year-old biogenic hematite in a banded iron formation of the Nuvvuagittuq Greenstone Belt in Canada; [30] graphite in 3.7 billion-year-old metasedimentary rocks in western Greenland; [31] and microbial mat fossils in 3.48 billion-year-old sandstone in Western Australia.