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Estrone sulfate, also known as E1S, E1SO4 and estrone 3-sulfate, is a natural, endogenous steroid and an estrogen ester and conjugate. [1] [2] [3]In addition to its role as a natural hormone, estrone sulfate is used as a medication, for instance in menopausal hormone therapy; for information on estrone sulfate as a medication, see the estrone sulfate (medication) article.
Estrone sulfate, the 3-sulfate conjugate of estrone. Estriol glucuronide, the 16α-glucuronide conjugate of estriol. An estrogen conjugate is a conjugate of an endogenous estrogen. They occur naturally in the body as metabolites of estrogens and can be reconverted back into estrogens.
Steroid sulfation is one of the most common of all forms of steroid conjugation. Except for cholesterol, dehydroepiandrosterone sulfate is the most abundant of all plasma steroids. Estrone sulfate is the most abundant of all the estrogens in the human body. [3] Estrone sulfate is synthesized by the enzyme estrone sulfotransferase.
The major estrogen in CEEs, sodium estrone sulfate, itself is inactive, and rather serves as a prodrug of estrone and then of estradiol. [1] [37] [38] The transformation of estrone sulfate to estrone is catalyzed by steroid sulfatase, and of estrone into estradiol by 17β-hydroxysteroid dehydrogenase.
E1S, also known as estrone 3-sulfate or as estra-1,3,5(10)-trien-17-one 3-sulfate, is a naturally occurring estrane steroid and a derivative of estrone. [15] It is an estrogen conjugate or ester, and is specifically the C3 sulfate ester of estrone. [15] Salts of E1S include sodium estrone sulfate and estropipate (piperazine estrone sulfate ...
Conjugated estrogens (Premarin) – 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg, 2.5 mg; Esterified estrogens (Amnestrogen, Estratab, Evex, Femogen, Menest) – 0.3 mg ...
Estrone is conjugated into estrogen conjugates such as estrone sulfate and estrone glucuronide by sulfotransferases and glucuronidases, and can also be hydroxylated by cytochrome P450 enzymes into catechol estrogens such as 2-hydroxyestrone and 4-hydroxyestrone or into estriol. [5]
An additional 21% of estrone sulfate is converted into estrone, whereas transformation of estrone into estrone sulfate is approximately 54%. [12] The interconversion between estradiol and estrone is mediated by 17β-hydroxysteroid dehydrogenases (17β-HSDs), [12] whereas the conversion of estrone into estrone sulfate is mediated by estrogen ...