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Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three [1] different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages.
21809 Ensembl ENSG00000119699 ENSMUSG00000021253 UniProt P10600 P17125 RefSeq (mRNA) NM_003239 NM_001329938 NM_001329939 NM_009368 RefSeq (protein) NP_001316867 NP_001316868 NP_003230 n/a Location (UCSC) Chr 14: 75.96 – 75.98 Mb Chr 12: 86.1 – 86.13 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transforming growth factor beta-3 is a protein that in humans is encoded by the ...
The transforming growth factor beta (TGF-β) superfamily is a large group of structurally related cell regulatory proteins that was named after its first member, TGF-β1, originally described in 1983. [2] They interact with TGF-beta receptors.
All three TGFβ1, TGFβ2 and TGFβ3. are synthesized as precursor molecules containing a propeptide region in addition to the TGF-β homodimer. [10] After it is synthesized, the TGF-β homodimer interact with a Latency Associated Peptide (LAP)[a protein derived from the N-terminal region of the TGF beta gene product] forming a complex called Small Latent Complex (SLC).
TGFBR3 is composed of an extracellular receptor domain consisting of 849 amino acids which is intracellularly connected to a short cytoplasmic domain. Betaglycan, being expressed by a whole range of various cell types within the organism, can be found in the form of a membrane-bound receptor, or as a soluble protein capable of interactions with the extracellular matrix ().
16998 Ensembl ENSG00000168056 ENSMUSG00000024940 UniProt Q9NS15 Q61810 RefSeq (mRNA) NM_001130144 NM_001164266 NM_021070 NM_008520 RefSeq (protein) NP_001123616 NP_001157738 NP_066548 NP_032546 Location (UCSC) Chr 11: 65.54 – 65.56 Mb Chr 19: 5.79 – 5.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Latent-transforming growth factor beta-binding protein 3 is a protein that in ...
Transforming growth factor ([attribution needed], or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ. The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms .
21810 Ensembl ENSG00000120708 ENSMUSG00000035493 UniProt Q15582 P82198 RefSeq (mRNA) NM_000358 NM_009369 RefSeq (protein) NP_000349 NP_033395 Location (UCSC) Chr 5: 136.03 – 136.06 Mb Chr 13: 56.76 – 56.79 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in ...