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2. Ondansetron - Wikipedia

   en.wikipedia.org/wiki/Ondansetron

   In 1997, ondansetron was the subject of a meta-analysis case study. Researchers examined 84 trials, with 11,980 people receiving ondansetron, published between 1991 and September 1996. Intravenous ondansetron 4 mg versus placebo was investigated in 16 reports and three further reports which had been duplicated a total of six times.

3. 5-HT3 antagonist - Wikipedia

   en.wikipedia.org/wiki/5-HT3_antagonist

   Comparative pharmacology of 5-HT 3 receptor antagonist [29] Drug Chemical nature Receptor antagonists T 1/2 (h) Metabolism Dose; Ondansetron: Carbazole derivative 5-HT 3 receptor antagonist and weak 5-HT 4 antagonist 3.9 hours CYP1A1/2, CYP2D6, CYP 3A3/4/5: 150 μg/kg Granisetron: Indazole: 5-HT 3 receptor antagonist 9–11.6 hours CYP3A3/4/5 ...

4. Aprepitant - Wikipedia

   en.wikipedia.org/wiki/Aprepitant

   Aprepitant, sold under the brand name Emend among others, is a medication used to prevent chemotherapy-induced nausea and vomiting and to prevent postoperative nausea and vomiting. [5] It may be used together with ondansetron and dexamethasone. [5] It is taken by mouth [5] or administered by intravenous injection. [3]

5. Metopimazine - Wikipedia

   en.wikipedia.org/wiki/Metopimazine

   Metopimazine is an approved prescription drug in France under the brand name Vogalene® [8] that has been used for the treatment of nausea and vomiting. [9] Vogalene® is available under different forms, including 15 mg capsules, 7.5 mg orally disintegrating tablets, 5 mg suppository, 0.1% oral liquid, and a 10 mg/mL intravenous (IV) solution approved for the prevention of chemotherapy-induced ...

6. Chemotherapy-induced nausea and vomiting - Wikipedia

   en.wikipedia.org/wiki/Chemotherapy-induced...

   In 1983, Coates et al. found that patients receiving chemotherapy ranked nausea and vomiting as the first and second most severe side effects, respectively. Up to 20% of patients receiving highly emetogenic agents in this era postponed, or even refused, potentially curative treatments. [ 1 ]

7. Drug action - Wikipedia

   en.wikipedia.org/wiki/Drug_action

   The action of drugs on the human body (or any other organism's body) is called pharmacodynamics, and the body's response to drugs is called pharmacokinetics. The drugs that enter an individual tend to stimulate certain receptors, ion channels, act on enzymes or transport proteins. As a result, they cause the human body to react in a specific way.

8. isoDMT - Wikipedia

   en.wikipedia.org/wiki/IsoDMT

   [1] [2] [4] [6] However, isoDMT retains significant activity at the serotonin 5-HT 2 receptors and shows psychoplastogenic effects comparable to those of serotonergic psychedelics in preclinical research. [7] [6] [8] [9] Its affinities (K i) for the serotonin 5-HT 2 receptors have been reported to be 600–650 nM for 5-HT 2A and 720 nM at 5-HT ...

9. Osemozotan - Wikipedia

   en.wikipedia.org/wiki/Osemozotan

   [1] [16] With the use of Osemozotan as a 5-HT 1A agonist, there is a decrease in serotonergic activity in the brain, leading to possible anti-obsessional pharmacological action. [6] One animal mouse model used to test for OCD is known as the marble burying test, in which the amount of marbles buried within a certain time frame is recorded. [ 6 ]